Sunday, January 4, 2009

Sugar-coated nanoparticles aid MRI diagnosis of disease-associated lesions in the brain

University of Oxford researchers have found that sugar coated nano particles will boost the effectiveness of MIR diagnosis of brain.

Prof Ben G. Davis

Benjamin G. Davis, Nicola R. Sibson, Daniel C. Anthony, and coworkers are the research team and they modified the ligand with an S-cyanomethyl linker that serves as a protecting group until the ligand is added to the nanoparticle. The team used the resulting glyconanoparticles as contrast agents in magnetic resonance imaging studies of rats afflicted with conditions similar to multiple sclerosis or stroke. The glyconanoparticles revealed lesions in these disease models at an earlier stage than did other MRI contrast agents, a result that the researchers suggest could lead to methods for earlier diagnoses.

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